PD Dr. Katrin Hurle

Chair of Mineralogy

Research associates

Address

Schlossgarten 5 91054 Erlangen

Contact

Email: katrin.hurle@fau.de

Research Focus

Characterization of apatite and brushite forming calcium phosphate cements modified with medical agents (antibiotics, bisphosphonates) for the application as pharmacologically active bone substitute
Substitution mechanisms of ionic dopants (Cu²⁺, Li⁺, Zn²⁺,…) in calcium phosphate phases, and their influence on the hydration reaction of calcium phosphate cements
Characterization of brushite cements optimized for 3D printing
Influence of organic additives (phytic acid, polyethylene glycol…) on the hydration performance of calcium phosphate cements
Quantitative XRD analysis of lithium silicate glass ceramics and ZrO2 ceramics for dental applications

Research Methods

Quantitative X-ray diffraction (QXRD) by Rietveld refinement combined with the G-factor method (external standard method); refinement of anisotropic crystallite sizes
I-Meter (automated Gillmore needle device) to determine the hardening performance of cements
Quantitative in-situ XRD, isothermal heat flow calorimetry and in-situ 1H-TD-NMR for the detailed characterization of cement hydration reactions
Influence of organic additives (phytic acid, polyethylene glycol…) on the hydration performance of calcium phosphate cements
Determination of specific surface area and particle size distribution by BET and laser diffraction

Research projects

Term: 1. April 2022 - 31. March 2024
Funding source: Deutscher Akademischer Austauschdienst (DAAD)
Project leader: Katrin Hurle, Friedlinde Götz-Neunhoeffer

Bone defects resulting from trauma, tumor removal or bone infections represent a major social challenge, exacerbated by the increasing proportion of elderly patients due to steadily rising life expectancy. The most effective treatment of such bone defects to improve the quality of life of those affected is therefore of high relevance. Despite the impressive progress in the development of synthetic materials for bone regeneration, some clinical problems still remain unsolved. Therefore, the aim…

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Term: since 1. July 2022
Funding source: DFG-Einzelförderung / Sachbeihilfe (EIN-SBH)
Project leader: Katrin Hurle

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Term: since 1. October 2021
Funding source: Deutsche Forschungsgemeinschaft (DFG)
Project leader: Friedlinde Götz-Neunhoeffer, Dominique de Ligny, Ulrich Lohbauer

Classes of materials that resemble natural teeth, such as polycrystalline ceramics, glass-ceramics and ceramic-methacrylate composites, have been preferred for tooth replacement for some time.

The first commercial product was based on a non-stoichiometric multi-component SiO2-Li2O-Al2O3-K2O-P2O5-ZrO2-ZnO system that was pre-crystallised, then melted and injected into a mould made of refractory material. The resulting glass-ceramics reached a degree of crystallisation of ~70 vol% with elongated…

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Term: 1. January 2019 - 31. December 2021
Project leader: Friedlinde Götz-Neunhoeffer

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Term: 1. January 2018 - 31. December 2019
Funding source: Deutscher Akademischer Austauschdienst (DAAD)
Project leader: Friedlinde Götz-Neunhoeffer, Katrin Hurle

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Term: 1. March 2017 - 31. May 2020
Funding source: DFG-Einzelförderung / Sachbeihilfe (EIN-SBH)
Project leader: Katrin Hurle

Bei der medizinischen Anwendung von Calciumphosphatzementen(CPCs) werden zunehmend minimal-invasive Eingriffe angestrebt, beidenen der Zement direkt in den Defekt injiziert wird. Problematisch istdabei oftmals die Phasenseparation von fester und flüssigerZementphase (filter-pressing). Das beantragte Forschungsprojektbefasst sich daher im ersten Teil mit der Modifizierung der Rheologieund damit der Injizierbarkeit von CPCs durch oberflächenladungstransferierende Additive. Ein bruschit- sowie e…

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Publications

2026

Belli R., Hartmann S., Lubauer J., Pereira RM., Hurle K., Yin L., Mieller B., Lohbauer U.:
Improving the chipping resistance of pre-sintered zirconia white-bodies
In: Dental Materials (2026)
ISSN: 0109-5641
DOI: 10.1016/j.dental.2025.12.012
Deuso SL., Müssig S., Stephani P., Conan R., Winzer B., Hurle K., Vogel N., Zákutná D., Mandel K.:
Supraparticles with Enhanced Mechanical and Signal Stability for Identification of Objects
In: ACS Applied Nano Materials 9 (2026), p. 5186-5197
ISSN: 2574-0970
DOI: 10.1021/acsanm.6c00108
Hurle K., Konrad JK., Gbureck U.:
Influence of the bisphosphonates alendronate, risedronate and zoledronic acid on the setting reaction of a hydroxyapatite-forming calcium phosphate cement
In: Ceramics International (2026)
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2026.02.413
Luthardt L., Müssig S., Hurle K., Zink A., Zhou X., Apeleo Zubiri B., Spiecker E., Mandel K.:
Tailorable Curie Temperature in Zinc Ferrite Nanoparticles With Finely Tunable Induction Heating Profiles Between Room Temperature and 250 °C
In: Small (2026), Article No.: e13314
ISSN: 1613-6829
DOI: 10.1002/smll.202513314
URL: https://onlinelibrary.wiley.com/doi/10.1002/smll.202513314?af=R

2025

Konrad JK., Rudnik J., Pöppler AC., Hurle K., Gbureck U.:
Interaction mechanisms between antibiotics and calcium phosphate cements as pharmacologically active bone graft substitutes
In: Acta Biomaterialia (2025)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2025.08.051
Raczka T., Groppe P., Hurle K., Moritz M., Papp C., Mandel K., Wintzheimer S.:
Thermite Reactions within Liquid Gallium/Iron Oxide Supraparticles Triggered Via Induction Heating
In: ACS Applied Nano Materials (2025)
ISSN: 2574-0970
DOI: 10.1021/acsanm.5c01171

2024

Bagci C., Bastan FE., Nawaz Q., Hurle K., de Ligny D., Boccaccini AR.:
Effects of silicon nitride (Si3N4) incorporation on physicochemical, bioactivity and antibacterial properties of 45S5 bioactive glass
In: Ceramics International 50 (2024), p. 50200-50212
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2024.09.367
Choudhary R., Indurkar A., Rubenis K., Grava A., Dubnika A., Hurle K., Locs J.:
Ultrafast and Reproducible Synthesis of Tailor-Made Octacalcium Phosphate
In: ACS Omega (2024)
ISSN: 2470-1343
DOI: 10.1021/acsomega.4c01436
Lohbauer U., Fabris DCN., Lubauer J., Abdelmaseh S., Cicconi MR., Hurle K., de Ligny D., Götz-Neunhoeffer F., Belli R.:
Glass science behind lithium silicate glass-ceramics
In: Dental Materials (2024)
ISSN: 0109-5641
DOI: 10.1016/j.dental.2024.03.006
Luthardt L., Raczka T., Hurle K., Müssig S., Mandel K.:
Customizable Induction Heating Profiles: from Tailored Colloidally Stable Nanoparticles Toward Multi-Stage Heatable Supraparticles
In: Advanced Functional Materials (2024), Article No.: 2412296
ISSN: 1616-301X
DOI: 10.1002/adfm.202412296
URL: https://onlinelibrary.wiley.com/doi/10.1002/adfm.202412296
Pereira RM., Belli R., Lohbauer U., Hurle K., Campos TMB., Thim GP.:
Fatigue strength of bilayer yttria-stabilized zirconia after low-temperature degradation
In: Journal of the Mechanical Behavior of Biomedical Materials 160 (2024), Article No.: 106725
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2024.106725
Späth K., Nawaz Q., Schilling T., Götz-Neunhoeffer F., Detsch R., Boccaccini AR., Hurle K.:
New Insights Into Application Relevant Properties of Cu2+-Doped Brushite Cements
In: Journal of Biomedical Materials Research Part B: Applied Biomaterials 112 (2024), Article No.: e35479
ISSN: 1552-4973
DOI: 10.1002/jbm.b.35479
Wolf A., Sauer J., Hurle K., Müssig S., Mandel K.:
Magnetic Supraparticles Capable of Recording High‐Temperature Events
In: Advanced Functional Materials (2024)
ISSN: 1616-301X
DOI: 10.1002/adfm.202316212

2023

Götz-Neunhoeffer F., Hurle K.:
Mineralogical characterization of calcium phosphate cements for clinical needs
In: J. Miguel Oliveira, Rui L. Reis, Sandra Pina (ed.): Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine, Elsevier, 2023, p. 199-217
ISBN: 9780323918213
DOI: 10.1016/B978-0-323-91821-3.00005-0
López Correa M., Teichert S., Ragazzola F., Cazorla Vázquez S., Engel F., Hurle K., Mazzoli C., Kuklinski P., Raiteri G., Lombardi C.:
Structural and geochemical assessment of the coralline alga Tethysphytum antarcticum from Terra Nova Bay, Ross Sea, Antarctica
In: Minerals 13 (2023)
ISSN: 2075-163X
DOI: 10.3390/min13020215
Nawaz Q., Pantulap U., Hurle K., Luo N., Grasso S., Boccaccini AR.:
Cold hydrostatic sintering of 45S5 bioactive glass
In: European Journal of Materials 3 (2023), p. 1-10
ISSN: 2688-9277
DOI: 10.1080/26889277.2023.2166876
Späth K., Götz-Neunhoeffer F., Hurle K.:
The effect of Cu2+ doping in β-tricalcium phosphate on the hydration mechanism of a brushite cement
In: Materials Today Chemistry 27 (2023), Article No.: 101288
ISSN: 2468-5194
DOI: 10.1016/j.mtchem.2022.101288
Weichhold J., Pfeiffle M., Kade JC., Hurle K., Gbureck U.:
Aqueous Calcium Phosphate Cement Inks for 3D Printing
In: Advanced Engineering Materials (2023)
ISSN: 1438-1656
DOI: 10.1002/adem.202300789

2022

Friedrich B., Lyer S., Janko C., Unterweger H., Brox R., Cunningham S., Dutz S., Taccardi N., Bikker FJ., Hurle K., Sebald H., Lenz M., Spiecker E., Fester L., Hackstein H., Strauss R., Boccaccini AR., Bogdan C., Alexiou C., Tietze R.:
Scavenging of bacteria or bacterial products by magnetic particles functionalized with a broad-spectrum pathogen recognition receptor motif offers diagnostic and therapeutic applications
In: Acta Biomaterialia 141 (2022), p. 418-428
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2022.01.001
Hurle K., Lubauer J., Belli R., Lohbauer U.:
On the assignment of quartz-like LiAlSi2O6 - SiO2 solid solutions in dental lithium silicate glass-ceramics: Virgilite, high quartz, low quartz or stuffed quartz derivatives?
In: Dental Materials (2022)
ISSN: 0109-5641
DOI: 10.1016/j.dental.2022.07.009
Hurle K., Maia FR., Ribeiro VP., Pina S., Oliveira JM., Götz-Neunhoeffer F., Reis RL.:
Osteogenic lithium-doped brushite cements for bone regeneration
In: Bioactive Materials (2022)
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2021.12.025
Hurle K., Weichhold J., Götz-Neunhoeffer F., Gbureck U.:
CONTROLLED ACTIVATION OF PREFABRICATED A-TRICALCIUM PHOSPHATE CEMENT PASTES STABILIZED BY SODIUM PYROPHOSPHATE
In: TISSUE ENGINEERING PART A, NEW ROCHELLE: 2022
Lubauer J., Belli R., Peterlik H., Hurle K., Lohbauer U.:
Grasping the Lithium hype: Insights into modern dental Lithium Silicate glass-ceramics
In: Dental Materials 38 (2022), p. 318-332
ISSN: 0109-5641
DOI: 10.1016/j.dental.2021.12.013
Wallis D., Harris J., Böhm C., Wang D., Zavattieri P., Feldner P., Merle B., Pipich V., Hurle K., Leupold S., Hansen LN., Marin F., Wolf S.:
Erratum: Progressive changes in crystallographic textures of biominerals generate functionally graded ceramics (Mater. Adv. (2022) DOI: 10.1039/d1ma01031j)
In: Materials Advances 3 (2022), p. 2598-
ISSN: 2633-5409
DOI: 10.1039/d2ma90020c
Weichhold J., Götz-Neunhoeffer F., Hurle K., Gbureck U.:
Pyrophosphate ions inhibit calcium phosphate cement reaction and enable storage of premixed pastes with a controlled activation by orthophosphate addition
In: Ceramics International 48 (2022), p. 15390-15404
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2022.02.073

2021

Belli R., Hurle K., Schürrlein J., Petschelt A., Werbach K., Peterlik H., Rabe T., Mieller B., Lohbauer U.:
Relationships between fracture toughness, Y2O3 fraction and phases content in modern dental Yttria-doped zirconias
In: Journal of the European Ceramic Society 41 (2021), p. 7771-7782
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2021.08.003
Contreras Jaimes AT., de Pablos-Martín A., Hurle K., Martins de Souza e Silva J., Berthold L., Kittel T., Boccaccini AR., Brauer DS.:
Deepening our understanding of bioactive glass crystallization using TEM and 3D nano-CT
In: Journal of the European Ceramic Society (2021)
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2021.02.051
Hurle K., Oliveira JM., Reis RL., Pina S., Götz-Neunhoeffer F.:
Ion-doped Brushite Cements for Bone Regeneration
In: Acta Biomaterialia (2021)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2021.01.004
Lubauer J., Belli R., Petschelt A., Cicconi MR., Hurle K., Lohbauer U.:
Concurrent kinetics of crystallization and toughening in multicomponent biomedical SiO2-Li2O-P2O5-ZrO2 glass-ceramics
In: Journal of Non-Crystalline Solids 554 (2021), Article No.: 120607
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2020.120607
Lubauer J., Hurle K., Cicconi MR., Petschelt A., Peterlik H., Lohbauer U., Belli R.:
Toughening by revitrification of Li2SiO3 crystals in Obsidian® dental glass-ceramic
In: Journal of the Mechanical Behavior of Biomedical Materials 124 (2021), Article No.: 104739
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2021.104739
Maqbool M., Nawaz Q., Ur Rehman MA., Cresswell M., Jackson P., Hurle K., Detsch R., Goldmann W., Shah AT., Boccaccini AR.:
Synthesis, characterization, antibacterial properties, and in vitro studies of selenium and strontium co-substituted hydroxyapatite
In: International Journal of Molecular Sciences 22 (2021), Article No.: 4246
ISSN: 1422-0067
DOI: 10.3390/ijms22084246
Nawaz Q., De Pablos-Martin A., Berthold L., De Souza E Silva JM., Hurle K., Boccaccini AR.:
Mapping the elemental and crystalline phase distribution in Cu2+ doped 45S5 bioactive glass upon crystallization
In: CrystEngComm (2021)
ISSN: 1466-8033
DOI: 10.1039/d1ce01160j
Wallis D., Harris J., Böhm C., Wang D., Zavattieri P., Feldner P., Merle B., Pipich V., Hurle K., Leupold S., Hansen LN., Marin F., Wolf S.:
Progressive changes in crystallographic textures of biominerals generate functionally graded ceramics
In: Materials Advances (2021)
ISSN: 2633-5409
DOI: 10.1039/d1ma01031j

2020

Kirsten J., Belli R., Wendler M., Petschelt A., Hurle K., Lohbauer U.:
Crack growth rates in lithium disilicates with bulk (mis)alignment of the Li2Si2O5 phase in the [001] direction
In: Journal of Non-Crystalline Solids 532 (2020), Article No.: 119877
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2019.119877
Myszka B., Schodder P., Leupold S., Barr M., Hurle K., Schüßler M., Demmert B., Biggemann J., Fey T., Boccaccini AR., Wolf S.:
Shape Matters: Crystal Morphology and Surface Topography Alter Bioactivity of Bioceramics in Simulated Body Fluid
In: Advanced Engineering Materials (2020)
ISSN: 1438-1656
DOI: 10.1002/adem.202000044
Nawaz Q., de Pablos-Martín A., Martins de Souza e Silva J., Berthold L., Hurle K., Contreras Jaimes AT., Sitarz M., Brauer DS., Boccaccini AR.:
Crystallization study of sol–gel derived 13-93 bioactive glass powder
In: Journal of the European Ceramic Society (2020)
ISSN: 0955-2219
DOI: 10.1016/j.jeurceramsoc.2020.09.052
Nawaz Q., de Pablos-Martín A., Martins de Souza e Silva J., Hurle K., Jaimes AT., Brauer DS., Boccaccini AR.:
New insights into the crystallization process of sol-gel–derived 45S5 bioactive glass
In: Journal of the American Ceramic Society (2020)
ISSN: 1551-2916
DOI: 10.1111/jace.17124
Späth K., Götz-Neunhoeffer F., Hurle K.:
Cu2+ doped β-tricalcium phosphate: Solid solution limit and crystallographic characterization by rietveld refinement
In: Journal of Solid State Chemistry 285 (2020), Article No.: 121225
ISSN: 0022-4596
DOI: 10.1016/j.jssc.2020.121225

2019

Belli R., Lohbauer U., Götz-Neunhoeffer F., Hurle K.:
Crack-healing during two-stage crystallization of biomedical lithium (di)silicate glass-ceramics
In: Dental Materials (2019)
ISSN: 0109-5641
DOI: 10.1016/j.dental.2019.05.013
Hurle K., Belli R., Götz-Neunhoeffer F., Lohbauer U.:
Phase characterization of lithium silicate biomedical glass-ceramics produced by two-stage crystallization
In: Journal of Non-Crystalline Solids 510 (2019), p. 42-50
ISSN: 0022-3093
DOI: 10.1016/j.jnoncrysol.2019.01.027
Lohbauer U., Belli R., Abdalla Alonso A., Götz-Neunhoeffer F., Hurle K.:
Effect of sintering parameters on phase evolution and strength of dental lithium silicate glass-ceramics
In: Dental Materials (2019)
ISSN: 0109-5641
DOI: 10.1016/j.dental.2019.07.002
Myszka B., Hurle K., Zheng K., Wolf S., Boccaccini AR.:
Mechanical improvement of calcium carbonate cements by: In situ HEMA polymerization during hardening
In: Journal of Materials Chemistry B 7 (2019), p. 3403-3411
ISSN: 2050-750X
DOI: 10.1039/c9tb00237e
Myszka B., Schüßler M., Hurle K., Demmert B., Detsch R., Boccaccini AR., Wolf S.:
Phase-specific bioactivity and altered Ostwald ripening pathways of calcium carbonate polymorphs in simulated body fluid
In: RSC Advances 9 (2019), p. 18232-18244
ISSN: 2046-2069
DOI: 10.1039/c9ra01473j
Weichhold J., Gbureck U., Götz-Neunhoeffer F., Hurle K.:
Setting mechanism of a CDHA forming α-TCP cement modified with sodium phytate for improved injectability
In: Materials 12 (2019), Article No.: 2098
ISSN: 1996-1944
DOI: 10.3390/ma12132098

2018

Hurle K., Weichhold J., Brueckner M., Gbureck U., Brueckner T., Götz-Neunhoeffer F.:
Hydration mechanism of a calcium phosphate cement modified with phytic acid
In: Acta Biomaterialia 80 (2018), p. 378-389
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2018.09.002

2017

Hurle K., Neubauer J., Götz-Neunhoeffer F.:
Hydration enthalpy of amorphous tricalcium phosphate resulting from partially amorphization of β-tricalcium phosphate
In: BioNanoMaterials 18 (2017), p. 429-440
ISSN: 2193-066X
DOI: 10.1515/bnm-2016-0016
Hurle K., Neubauer J., Götz-Neunhoeffer F.:
Hydration mechanism of partially amorphized β-tricalcium phosphate
In: Acta Biomaterialia 54 (2017), p. 429-440
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2017.03.013
Toniolo N., Taveri G., Hurle K., Roether J., Ercole P., Dlouhy⁠ I., Boccaccini AR.:
Fly-ash-based geopolymers: How the addition of recycled glass or red mud waste influences the structural and mechanical properties
In: Journal of Ceramic Science and Technology 8 (2017), p. 411-419
ISSN: 2190-9385
DOI: 10.4416/JCST2017-00053

2016

Hurle K., Christel T., Gbureck U., Moseke C., Neubauer J., Götz-Neunhoeffer F.:
Reaction kinetics of dual setting α-tricalcium phosphate cements
In: Journal of Materials Science: Materials in Medicine 27 (2016), p. 1-13
ISSN: 0957-4530
DOI: 10.1007/s10856-015-5616-y

2015

Hurle K., Neubauer J., Bohner M., Doebelin N., Götz-Neunhoeffer F., Götz-Neunhoeffer F.:
Calorimetry investigations of milled alpha-tricalcium phosphate (alpha-TCP) powders to determine the formation enthalpies of alpha-TCP and X-ray amorphous tricalcium phosphate
In: Acta Biomaterialia 2015 (2015)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2015.05.026
Hurle K., Neubauer J., Götz-Neunhoeffer F.:
Influence of Sr2+ on Calcium-Deficient Hydroxyapatite Formation Kinetics and Morphology in Partially Amorphized α-TCP
In: Journal of the American Ceramic Society 99 (2015), p. 1055-1063
ISSN: 1551-2916
DOI: 10.1111/jace.14005

2014

Hurle K., Neubauer J., Bohner M., Döbelin N., Götz-Neunhoeffer F.:
Effect of amorphous phases during the hydraulic conversion of alpha-TCP into calcium-deficient hydroxyapatite
In: Acta Biomaterialia 10 (2014), p. 3931-3941
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2014.03.017

Address

Contact

Research Focus

Research Methods

Research projects

2022

PPP-Portugal 2022-2024: 3D printing of Li-Brushite/silk fibroin nanocomposites for bone regeneration.

Wechselwirkungsmechanismen von medizinischen Wirkstoffen mit Calciumphosphatzementen für die Anwendung als pharmakologisch aktiver Knochenersatzstoff

2021

Li-Silicates: Development of SiO2 – Li2O – P2O5 – ZrO2 dental glass-ceramic systems with extended lifetimes: crystallization mechanisms and resistance to subcritical crack growth

2019

Cu-doped beta TCP: Crystallographic analysis of Cu2+ doped β-tricalcium phosphate by Rietveld refinement and influence on the hydration kinetics

2018

Enzymatisch aktiviertes Abbinden dotierter Calciumphosphatzemente

2017

Mechanistische Analyse von Mineralisationsvorgängen in modifizierten anorganischen Knochenzementen mit enzymatischer Kontrolle der Abbindereaktion

Publications

2026

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014